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Open Journal of Oncology

ISSN: 2075-9096
Volume 4, 2017

Open Journal of Oncology, 2012, 2-1 [Case Report]

High Grade Glioma after Prophylactic Cranial Irradiation for Small Cell Lung Cancer
Andra Krauze1, Samir Patel1, Don Yee1, Lothar Resch2, Anil Joy3, Aalo Bistritz4, Natalie Logie5, Dorcas Fulton3, Alysa Fairchild1
1 Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Canada
2 Department of Pathology, University of Alberta Hospital, Edmonton, Canada
3 Division of Medical Oncology, Cross Cancer Institute, Edmonton, Canada
4 Division of Radiology, Cross Cancer Institute, Edmonton, Canada
5 Faculty of Medicine, University of Alberta, Edmonton, Canada

Corresponding Author & Address:

Alysa Fairchild
Division of Radiation Oncology, Cross Cancer Institute, 11560 University Avenue, Edmonton, AB T6G 1Z2, Canada; Tel: +1-780-432-8516; Fax: +1-780-432-8380; Email: alysa.fairchild@albertahealthservices.ca

Article History:
Published: 16th June, 2012   Accepted: 16th June, 2012
Received: 24th April, 2012      

© Fairchild et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.


We report a patient with an initial diagnosis of small cell lung cancer treated with prophylactic cranial irradiation (PCI), who subsequently developed a second primary brain neoplasm within the PCI volume. Pathology review was consistent with astrocytoma, WHO grade IV (Glioblastoma Multiforme). After describing our case, we review the literature on the development of a second brain primary after treatment with PCI and discuss potential etiologies.

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