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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017



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Open Journal of Hematology, 2017, 8-1 [Research Article]

Incompatible blood transfusion in children in Burkina Faso

Eléonore Kafando1, Lady Rosny Wandji Nana1, Yacouba Domo2, Yacouba Nébié2, Dorcas Obiri-Yeboah3, Jacques Simporé4

1 Hôpital Universitaire Pédiatrique Charles de Gaulle 01 BP1198 Ouagadougou, Burkina Faso
2 National Blood Transfusion Centre, Avenue Kunda-Yoonré, 01 BP 5372, Ouagadougou, Burkina Faso
3 Department of Microbiology, School of Medical Sciences, University of Cape Coast, Ghana
4 Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA)/LABIOGENE, Université Ouaga I Professeur Joseph KI-ZERBO; 01 BP 364 Ouagadougou 01 Ouagadougou, Burkina Faso

Corresponding Author & Address:

Kafando Eléonore*
Hôpital Universitaire Pédiatrique Charles de Gaulle 01 BP1198 Ouagadougou, Burkina Faso;
Email: ekafando@hotmail.com

Article History:
Published: 23rd January, 2017   Accepted: 23rd January, 2017
Received: 12th December, 2016  

© Eléonore et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.

Keywords: incompatible blood, alloimmunization, red blood cell, children

Abstract:

Background: Transfusion therapy saves lives, but remains complicated by RBC immunization. So, erythrocyte phenotyping in blood donors and recipients is crucial in minimizing alloimmunization.

Objectives: To determine the frequency of Rhesus and Kell incompatible red blood cell transfusions in children.

Methods: A cross-sectional observational study was conducted in two paediatric health centres in Ouagadougou, Burkina Faso. Usually, standard phenotyping, ABO and RhD was determined for transfusion. Extended phenotyping i.e. RhC, RhE, Rhc, and Rhe and Kell antigens, was determined in both the recipients and the donor red blood cell units as well. The samples were analyzed using the LISS-Coombs indirect antiglobulin test to determine if alloimmunization had occurred.

Results:Out of the 474 transfused children, a haemoglobin level under 70g/L was observed in 86% of them, malaria (49%) was the main indication for blood transfusion and incompatible Rhesus /Kell transfusions were demonstrated in 25% of the cases. The red cell alloimmunization was observed in 4.2% of the patients.

Conclusions: Performing erythrocyte phenotyping in donors and recipients will diminish the risk of alloimmunization in children receiving multiple transfusions later in life.



©2017 Ross Science Publishers