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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017



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Open Journal of Hematology, 2015, 6-2 [Research Article]

PROGNOSTIC FACTORS OF NON-HODGKIN LYMPHOMA: RETROSPECTIVE STUDY IN UNIT BLOOD SERVICE OF THE INTERNAL MEDICINE DANTEC IN DAKAR (SENEGAL)

Fatou Samba Diago Ndiaye, Seynabou Fall, Atoumane Faye, Nafissatou Diagne, Awa Cheikh Ndaw, Boundia Djiba, Abdoulaye Pouye

Unit of Hematology in Le Dantec hospital, Cheikh Anta Diop University, Dakar, Senegal

Corresponding Author & Address:

Fatou Samba Diago Ndiaye*
Unit of Hematology in Le Dantec hospital, Cheikh Anta Diop University, Avenue Pasteur BP : 10599  Dakar Liberte, Dakar, Senegal; Phone: 221 775299844/ +221776124484; Email: kinepierre1@yahoo.fr

Article History:
Published: 13th April, 2015   Accepted: 13th April, 2015
Received: 16th January, 2015   Revised: 4th March, 2015

© Ndiaye et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.

Keywords: prognostic factors, lymphomas

Abstract:

INTRODUCTION: The non-Hodgkin's lymphoma is the monoclonal proliferation of B and T lymphocyte cells, responsible for the development of tumors in lymphoid organs. The objective of this study was to describe the prognostic factors for NHL and their impact in the care of patients

METHODOLOGY: This is a descriptive retrospective study on patients hospitalized files Medical Clinic I of the Aristide Le Dantec Hospital from January 2005 to December 2009. Were included in the study, patients for whom diagnosis of non-Hodgkin lymphoma was made on the basis of the results of histological and / or immuno-phenotypic examination of the biopsy specimen. Prognostic factors were studied and classified according to the prognostic scores in order to assess their impact on patient survival. Data analysis was done thanks to the IPSS software and the significance level was set at p ≤ 5%.

RESULTS: NHL 44 cases represented on all patients hospitalized for haematological malignancies during this period, a prevalence of 45.4%. We have noted an increase in the incidence of NHL 2005 to 2009. The sex ratio was 2.6 / 1 and the mean age was 46.77 years [17-78 years]. Among the general symptoms, fever and weight loss were in the forefront (61.4% of patients) and lymph nodes were the most frequent physical signs (75%) followed by splenomegaly (47.7%). anemia was found in 72.7% of cases, leukocytosis in 45.5% of cases and thrombocytopenia in 47.7% of patients. Thirty-seven point four percent of patients were classified stage IV Ann Arbor at diagnosis. The presence of general signs scalability B was observed in 70% of patients. Regarding the prognostic factors, the International Prognostic Index (IPI) was studied in 43.2% of patients (n = 19) patients showed that 16% (n = 3) were IPI 1; 37% (n = 7) had an intermediate risk (IPI 3 and 4) and the remaining 10% were high risk (IPI 4). The IPI adjusted for age (aaIPI), noted a correlation of the IPI with certain age groups (50 and 60 years, p = 0.00001, 60 and 70, p = 0.00001). All patients were classified LLC Binet stage C and FLIPI was low (1-2). Evolution were marked by a 100% survival for low-risk patients (with a statistically significant correlation between survival and IPI 1: p <0.00001) and a death rate of 100% for high-risk patients (p <0.00001). The evolution was marked by a prolonged clinical and laboratory remission in 61.3% of cases, 11.4% of patients lost to 27.4% of deceased patients.

CONCLUSION: Poor prognostic factors for lymphomas are mainly represented by the advanced Ann Arbor, international prognostic index (IPI) high and the presence of clinical signs of disease progression of the dice inclusion.



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