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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017



Indexed in:
EMBASE

Open Journal of Hematology, 2014, 5-7 [Case Report]

Acute human parvovirus B19 infection in a 6-year old girl with sickle cell disease: a case report

Daniele Donà1,*, Federica Visentin2, Eleonora Borgia1, Stefania Scanferla2, Carlo Giaquinto1, Raffaella Colombatti3, Laura Sainati3

1 Division of Pediatric Infectious Diseases, Department for Woman and Child Health, University of Padova, Padova, Italy
2 Division of Pediatric Emergency Care, Department for Woman and Child Health, University Hospital of Padova, Padova Italy
3 Division of Pediatric Hematology-Oncology, Department for Woman and Child Health, University of Padova, Padova, Italy

Corresponding Author & Address:

Daniele Donà*
Division of Pediatric Infectious Diseases, Department for Woman and Child Health, University Hospital of Padova, Padova Italy, Via Giustiniani 3, 35124 Padova, Italy; Email: daniele.dona@studenti.unipd.it; Phone: +39 3388946412; Fax: +39 049 8213617

Article History:
Published: 7th October, 2014   Accepted: 7th October, 2014
Received: 6th July, 2014   Revised: 27th August, 2014

© Donà et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.

Keywords: Acute Splenic Sequestration, Intravenous immunoglobulin treatment, Sickle-cell disease

Abstract:

A 6-year-old girl with Sickle-cell disease was hospitalized because of fever and arthralgia. During hospitalization she developed a splenic sequestration with the need of three successive red packed-cell transfusions. Microbiological investigations revealed positive HPVB19 IgM and IgG and HPVB19 DNA in blood. Given the diagnosis of HPVB19 infection and persistent fever, she received intravenous immunoglobulins (IVIg) with progressive clinical improvement and discharge after 24 days of hospitalization. This is the first case of acute HPVB19 infection in a child with Sickle cell disease and more than 20 days fever, associated with splenic sequestration. IVIg may represent an effective therapy.



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