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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017



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Open Journal of Hematology, 2013, 4-2 [Case Report]

B Cell Acute Lymphoblastic Leukemia Associated with t(8;22)(p11.2q11.2): Role of Additional Cytogenetic Anomalies

Kate M. Serdy, Shireen R. Khoury, Louis DePalma

Department of Pathology, George Washington University Medical Center, Washington, DC

Corresponding Author & Address:

Shireen Khoury*
George Washington University Medical Center, 900 23rd St, NW, Washington, DC 20037; Fax: (202) 715.4691; Email: shireen@gwmail.gwu.edu

Article History:
Published: 26th June, 2013   Accepted: 26th June, 2013
Received: 9th April, 2013   Revised: 15th May, 2013

© Khoury et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.

Abstract:

B lymphoblastic leukemia (B-ALL) may be associated with recurrent cytogenetic and molecular abnormalities. We describe the fourth-known case of B-ALL associated with the t(8;22)(p11.2q11.2) – a translocation seen more frequently in T lymphoblastic leukemia and acute myelogenous leukemia. This patient’s leukemia involves a combination of additional cytogenetic anomalies not yet described in the literature, including del(11)(q13q23), add(9)(p22), and monosomy 7. Given the role in B cell differentiation of genes in the affected regions, including MEN1 (11q13), ATM (11q22), ETS1(11q23), MLL (11q23), AF9 (9p22), and IKZ-F1 (7p12), this case may provide further insight into B cell leukemogenesis associated with the t(8;22). Deletion or mutation of these genes may be critical in targeting the B cell population, and this cytogenetic profile of a B-ALL suggests additional gene targets for diagnostic and therapeutic consideration.



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