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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017



Indexed in:
EMBASE

Open Journal of Hematology, 2012, 3(S1)-5 [Mini-Review]

Chemokine Regulation of Cell Trafficking in Lung Cancer Metastasis

Leena Gandhi, Kwok Kin Wong
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Corresponding Author & Address:

Leena Gandhi
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;
Email: Leena_Gandhi@dfci.harvard.edu
Kwok Kin Wong
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;
Email: kwok-kin_wong@dfci.harvard.edu

Article History:
Published: 21st February, 2012   Accepted: 21st February, 2012
Received: 11th October, 2011      

© Gandhi et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.

Abstract:

Chemokine regulation of cell trafficking has been identified as a critical pathway in metastatic progression. This review focuses on the role of the CXCR4-CXCL12-CXCR7 axis in regulating lung cancer invasion and metastasis. All of these factors have been identified as overexpressed in lung cancer specimens and in most cases are associated with poorer outcome. Preclinical studies have demonstrated an important role for CXCR4 in the steps of invasion, cell migration, and stromal cell adhesion and have suggested that CXCR4 is associated with “stem-like” cells that may be critical for initiating metastases. These data, together with emerging preclinical data on the efficacy of CXCR4 inhibitors suggests that CXCR4 should be explored as a clinical target for blocking metastatic progression in lung cancer.



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