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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017



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EMBASE

Open Journal of Hematology, 2012, 3(S1)-4 [Review Article]

Cell Trafficking in Multiple Myeloma

Giada Bianchi1, Shaji Kumar1, Irene M. Ghobrial2, Aldo M. Roccaro2
1 Mayo Clinic, Rochester, MN, USA
2 Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Corresponding Author & Address:

Giada Bianchi
Mayo Clinic, Rochester, MN, USA; Email: bianchi.giada@mayo.edu
Aldo M. Roccaro
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;
Email:  Aldo_roccaro@dfci.harvard.edu

Article History:
Published: 21st February, 2012   Accepted: 21st February, 2012
Received: 19th October, 2011      

© Bianchi and Roccaro et al.; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.

Abstract:

Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells (PC) and represents the second most frequent hematologic malignancy in the western world. MM cells localize preferentially to the bone marrow where they interact closely with bone marrow stroma cells (BMSC) and extracellular matrix (ECM) proteins in a reciprocal pro-survival loop. Such a bone marrow niche guarantees a survival advantage for MM cells and has a crucial role in mediating drug resistance to chemotherapy agents. As the name suggests, hallmark characteristic of MM is the ability to localize in multiple, distant bone sites causing disruption of the normal bone architecture and impairment of normal hematopoiesis. The pathogenic mechanisms of MM rely then not only on proliferation of cancerous cells, but also on the ability of myeloma cells to traffic between sites and home to appropriate survival niches.

Identifying the mechanisms that regulate the homing of MM cells to the bone marrow, the MM-BMSC interaction and the trafficking of MM cells from the bloodstream to distant bone locations is therefore crucial to design new, more effective therapies capable of overcoming the maladaptive interaction between BMSCs and MM and help in finding a cure for MM.



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