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Open Journal of Hematology

ISSN: 2075-907X
Volume 8, 2017

Indexed in:

Open Journal of Hematology, 2012, 3-5 [Mini-Review]

Is blood transfusion therapy the ideal treatment for β-thalassemia intermedia?

Katerina Constantinou
Facultyof Medicine, Imperial College London, London, UK

Corresponding Author & Address:

Katerina Constantinou*
Faculty of Medicine, Imperial College,South Kensington Campus, Exhibition Road, London SW7 2AZ;
Email: katerina.constantinou08@imperial.ac.uk

Article History:
Published: 17th November, 2012   Accepted: 17th November, 2012
Received: 27th August, 2012   Revised:  25th September, 2012

© Katerina Constantinou; licensee Ross Science Publishers

ROSS Open Access articles will be distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided that the original work will always be cited properly.


The thalassemias represent the most common single gene disorder worldwide. The total annual incidence of symptomatic individuals with β-thalassemia is estimated at 1 in 100,000 throughout the world [1] of which nearly 10% have β-thalassemia intermedia (TI) [2]. Several approaches have been used for treating patients with TI including blood transfusions, splenectomy, iron chelation therapy, modulation of foetal haemoglobin and other agents focusing on specific aspects of clinical presentation. However the exact management of the disease is still controversial. A major issue which is not entirely explored is the effect of blood transfusion in the management of patients with β-thalassemia intermedia. There are certain advantages and disadvantages of initiating blood transfusions in TI patients that must be always taken into account in the management of these patients. Therefore, complications that interact with the clinical outcome of treatment and also patient’s quality of life can be avoided to some extend.


  1. Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010; 5: 11.
  2. Rachmilewitz EA, Giardina PJ. How I treat thalassemia. Blood. 2011; 118: 3479-88.

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